If your aches and pains are serious, you’ll want something extra strong to get the job done. Luckily, there are plenty of options on the market to help relieve your discomfort. Some creams rely on counterirritants such as menthol and camphor to cool and soothe the skin, while others use powerful ingredients like salicylates (a non-steroidal anti-inflammatory drug that blocks a key enzyme in the inflammation process) or lidocaine to numb the pain. The best high potency pain relief cream will offer fast-acting and targeted relief from muscle soreness, arthritis flares, and stress/tension headaches.

A standout option is Cymbiotika Ultimate Pain Balm, which combines multiple natural extracts to provide powerful and targeted relief for aches and pains. Bromelain, an extract from pineapples, has been shown to have both anti-inflammatory and analgesic properties while arnica helps calm the skin. The cooling blend of menthol, peppermint, and ginger creates a balanced aroma that’s both soothing and refreshing. Plus, the lightweight, non-greasy formula is easy to apply and will not stain clothing.

Top Picks: Best High Potency Pain Relief Creams

For an even more comprehensive solution, this pain relief cream from Neosporin combines an anti-itch cream with a numbing ointment to treat all of your symptoms in one product. Pramoxine hydrochloride alleviates itching while the numbing ointment (with 4% lidocaine, the maximum amount you can legally use without a prescription) treats aches and pains from arthritis, backaches, and strains or sprains.

Other high potentcy pain relief creams include Aspercreme, which is formulated with menthol, methyl salicylate, and capsaicin to create a cooling sensation that dulls and relieves aches and pains from sprains, bruises, and arthritis. This formula has been lauded by reviewers for its ability to deliver quick relief for pain and stiffness in the knees, elbows, back, and shoulders. However, some reviewers note that it may sting sensitive skin. If you have any concerns, test it on a small patch of skin before slathering it all over.